Clotrimazole

Clotrimazole
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Other Brands/Names

Baycuten-N, Bernesten, Beytuce, Candacort, Candazole, Canesten, Cotristen, Fungiderm, Dermifar, Erphamazol, Heltiskin, Katisililine.

 

How It Works

Clotrimazole is an antifungal medication that works by disrupting the protective barrier of fungal cells. It achieves this by inhibiting the production of ergosterol, which is a key building block in the structure of fungal cells. This disruption prevents fungal growth and ultimately leads to the death of the fungal cells.

 

Indications

Clotrimazole is used to treat various fungal infections, including:

  • Fungal infections of the skin, such as tinea versicolor and ringworm

  • Fungal infections of the external ear canal (otitis externa)

  • Fungal infections of the female genital tract, such as candidiasis (yeast infection) and trichomoniasis vaginalis

 

Contraindications

Clotrimazole should not be used by individuals with a known history of hypersensitivity or allergies to the medication. Symptoms of allergic reactions may include hives or swelling of the eyelids.

 

Side Effects

While side effects are generally rare, some may occur, including:

  • Local burning sensation

  • Hives or blisters

  • Itching

  • Peeling skin

  • Redness or swelling

  • Pain or other signs of irritation

 

Types

Clotrimazole is available in several forms:

  • Cream

  • Vaginal tablets (prescription-only)

 

Dosage

Adult dosage

  • Cream

Apply the cream to the affected area 2-3 times daily for 2 weeks, even after the skin condition appears to have healed. Squeeze out a fingertip-sized amount of clotrimazole or as needed and apply to the affected area.

  • Vaginal Tablets

Insert two 100 mg vaginal tablets into the vagina for 3 consecutive days, preferably before bedtime.

Children dosage

  • Cream

The dosage and administration are the same as for adults.

 

Safety

Pregnancy:

Clotrimazole is classified as FDA Category B (animal studies have shown no fetal abnormalities, but there are no adequate and well-controlled studies in pregnant women). It is generally considered safe for use during pregnancy, but its use should still be discussed with a healthcare provider.

 

Drug Interactions

Other topical medications (e.g., tacrolimus): Using clotrimazole with certain topical medications may increase the levels of tacrolimus, raising the risk of side effects.

 

Looking for more information about other drugs? Click here!

 

Writer : dr Apri Haryono Hafid
Editor :
  • dr Hanifa Rahma
Last Updated : Sunday, 10 August 2025 | 23:32

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Mims Indonesia. Clotrimazole. Retrieved 14 January 2022, from: https://www.mims.com/indonesia/drug/info/clotrimazole?mtype=generic 

Badan Pengawas Obat dan Makanan. Klotrimazol. Retrieved 14 January 2022, from: https://pionas.pom.go.id/monografi/klotrimazol 

Badan Pengawas Obat dan Makanan. Klotrimazol. Retrieved 14 January 2022, from: https://pionas.pom.go.id/monografi/klotrimazol-0 

Drugs.com. Clotrimazole. Retrieved 14 January 2022, from: https://www.drugs.com/mtm/clotrimazole-topical.html 

 

Medscape. Clotrimazole. Retrieved 14 January 2022, from: https://reference.medscape.com/drug/gyne-lotrimin-3-combination-pack-gyne-lotrimin-3-vaginal-cream-clotrimazole-342586#0